![]() They forget they are blood, heart and skin cells, making them perfect for rebirth as “cell du jour,” but lousy at rejuvenation. However, adult cells fully switched back to stem cells via Yamanaka factors lose their identity. The 2007 discovery won the scientist a Nobel Prize, and his “induced pluripotent stem cells,” soon became known as “Yamanaka factors.” Shinya Yamanaka had already reprogrammed human adult skin cells to behave like embryonic or pluripotent stem cells, capable of developing into any cell in the body. If that could be done, Sinclair asked his team, could the reverse be accomplished as well? Japanese biomedical researcher Dr. Yet they are brother and sister, born from the same litter – only one has been genetically altered to age faster. One is the picture of youth, the other gray and feeble. ![]() In Sinclair’s lab, two mice sit side by side. “I believe that in the future, delaying and reversing aging will be the best way to treat the diseases that plague most of us.” Memory comes back there is no more dementia. “We know that when we reverse the age of an organ like the brain in a mouse, the diseases of aging then go away. While modern medicine addresses sickness, it doesn’t address the underlying cause, “which for most diseases, is aging itself,” Sinclair said. Now he wants to change the world and make aging a disease,” said Whitney Casey, an investor who is partnering with Sinclair to create a do-it-yourself biological age test. ![]() “His research shows you can change aging to make lives younger for longer.
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